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Synthesis of C(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step
We demonstrate a new synthetic strategy toward star-shaped C(3)-symmetric molecules containing α-amino acid (AAA) derivatives and dipeptides. In this regard, trimerization and Negishi cross-coupling reactions are used as the key steps starting from readily available 4’-iodoacetophenone and L-serine....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369998/ https://www.ncbi.nlm.nih.gov/pubmed/30800186 http://dx.doi.org/10.3762/bjoc.15.33 |
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author | Kotha, Sambasivarao Todeti, Saidulu |
author_facet | Kotha, Sambasivarao Todeti, Saidulu |
author_sort | Kotha, Sambasivarao |
collection | PubMed |
description | We demonstrate a new synthetic strategy toward star-shaped C(3)-symmetric molecules containing α-amino acid (AAA) derivatives and dipeptides. In this regard, trimerization and Negishi cross-coupling reactions are used as the key steps starting from readily available 4’-iodoacetophenone and L-serine. These C(3)-symmetric molecules containing AAA moieties are useful to design new ligands suitable for asymmetric synthesis and peptide dendrimers. |
format | Online Article Text |
id | pubmed-6369998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-63699982019-02-22 Synthesis of C(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step Kotha, Sambasivarao Todeti, Saidulu Beilstein J Org Chem Full Research Paper We demonstrate a new synthetic strategy toward star-shaped C(3)-symmetric molecules containing α-amino acid (AAA) derivatives and dipeptides. In this regard, trimerization and Negishi cross-coupling reactions are used as the key steps starting from readily available 4’-iodoacetophenone and L-serine. These C(3)-symmetric molecules containing AAA moieties are useful to design new ligands suitable for asymmetric synthesis and peptide dendrimers. Beilstein-Institut 2019-02-08 /pmc/articles/PMC6369998/ /pubmed/30800186 http://dx.doi.org/10.3762/bjoc.15.33 Text en Copyright © 2019, Kotha and Todeti https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Full Research Paper Kotha, Sambasivarao Todeti, Saidulu Synthesis of C(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step |
title | Synthesis of C(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step |
title_full | Synthesis of C(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step |
title_fullStr | Synthesis of C(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step |
title_full_unstemmed | Synthesis of C(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step |
title_short | Synthesis of C(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via Negishi coupling as a key step |
title_sort | synthesis of c(3)-symmetric star-shaped molecules containing α-amino acids and dipeptides via negishi coupling as a key step |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369998/ https://www.ncbi.nlm.nih.gov/pubmed/30800186 http://dx.doi.org/10.3762/bjoc.15.33 |
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