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Targeting EZH2 in Multiple Myeloma—Multifaceted Anti-Tumor Activity
The enhancer of zeste homolog 2 (EZH2) is the enzymatic subunit of the polycomb repressive complex 2 (PRC2) that exerts important functions during normal development as well as disease. PRC2 through EZH2 tri-methylates histone H3 lysine tail residue 27 (H3K27me3), a modification associated with repr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370027/ https://www.ncbi.nlm.nih.gov/pubmed/30761216 http://dx.doi.org/10.3390/epigenomes2030016 |