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mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase, to accumulation of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370368/ https://www.ncbi.nlm.nih.gov/pubmed/30788416 http://dx.doi.org/10.1080/23723556.2018.1537709 |