mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase, to accumulation of...

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Detalles Bibliográficos
Autores principales: Drusian, Luca, Boletta, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370368/
https://www.ncbi.nlm.nih.gov/pubmed/30788416
http://dx.doi.org/10.1080/23723556.2018.1537709
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author Drusian, Luca
Boletta, Alessandra
author_facet Drusian, Luca
Boletta, Alessandra
author_sort Drusian, Luca
collection PubMed
description Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase, to accumulation of the oncometabolite fumarate, and gradual transformation from benign cysts into cystadenomas and papillary carcinomas.
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spelling pubmed-63703682019-11-20 mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression Drusian, Luca Boletta, Alessandra Mol Cell Oncol Author’s Views Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase, to accumulation of the oncometabolite fumarate, and gradual transformation from benign cysts into cystadenomas and papillary carcinomas. Taylor & Francis 2018-11-20 /pmc/articles/PMC6370368/ /pubmed/30788416 http://dx.doi.org/10.1080/23723556.2018.1537709 Text en © 2018 The Author(s). Published by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Drusian, Luca
Boletta, Alessandra
mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
title mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
title_full mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
title_fullStr mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
title_full_unstemmed mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
title_short mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
title_sort mtorc1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370368/
https://www.ncbi.nlm.nih.gov/pubmed/30788416
http://dx.doi.org/10.1080/23723556.2018.1537709
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