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Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI
Irreversible white matter (WM) damage, including severe demyelination and axonal loss, is a main determinant of long-term disability in multiple sclerosis (MS). Non-invasive detection of changes in microstructural WM integrity in the disease is challenging since commonly used imaging metrics lack th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370560/ https://www.ncbi.nlm.nih.gov/pubmed/30739842 http://dx.doi.org/10.1016/j.nicl.2019.101699 |