Nkx2–5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation

The cardiac transcription factor Nkx2-5 is essential for normal outflow tract (OFT) and right ventricle (RV) development. Nkx2-5(−/−) null mouse embryos display severe OFT and RV hypoplasia and a single ventricle phenotype due to decreased proliferation of Second Heart Field (SHF) cells, a pool of c...

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Detalles Bibliográficos
Autores principales: Horton, Anthony J., Brooker, John, Streitfeld, William S., Flessa, Meaghan E., Pillai, Balakrishnan, Simpson, Raychel, Clark, Christopher D., Gooz, Monika B., Sutton, Kimberly K., Foley, Ann C., Lee, Kyu-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370788/
https://www.ncbi.nlm.nih.gov/pubmed/30742009
http://dx.doi.org/10.1038/s41598-019-39078-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370788/
https://www.ncbi.nlm.nih.gov/pubmed/30742009
http://dx.doi.org/10.1038/s41598-019-39078-5

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