A mutation in the AdhE alcohol dehydrogenase of Clostridium thermocellum increases tolerance to several primary alcohols, including isobutanol, n-butanol and ethanol

Clostridium thermocellum is a good candidate organism for producing cellulosic biofuels due to its native ability to ferment cellulose, however its maximum biofuel titer is limited by tolerance. Wild type C. thermocellum is inhibited by 5 g/L n-butanol. Using growth adaptation in a chemostat, we inc...

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Detalles Bibliográficos
Autores principales: Tian, Liang, Cervenka, Nicholas D., Low, Aidan M., Olson, Daniel G., Lynd, Lee R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370804/
https://www.ncbi.nlm.nih.gov/pubmed/30741948
http://dx.doi.org/10.1038/s41598-018-37979-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370804/
https://www.ncbi.nlm.nih.gov/pubmed/30741948
http://dx.doi.org/10.1038/s41598-018-37979-5

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