NADP(+) is an endogenous PARP inhibitor in DNA damage response and tumor suppression

ADP-ribosylation is a unique posttranslational modification catalyzed by poly(ADP-ribose) polymerases (PARPs) using NAD(+) as ADP-ribose donor. PARPs play an indispensable role in DNA damage repair and small molecule PARP inhibitors have emerged as potent anticancer drugs. However, to date, PARP inh...

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Detalles Bibliográficos
Autores principales: Bian, Chunjing, Zhang, Chao, Luo, Tao, Vyas, Aditi, Chen, Shih-Hsun, Liu, Chao, Kassab, Muzaffer Ahmad, Yang, Ying, Kong, Mei, Yu, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370829/
https://www.ncbi.nlm.nih.gov/pubmed/30741937
http://dx.doi.org/10.1038/s41467-019-08530-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370829/
https://www.ncbi.nlm.nih.gov/pubmed/30741937
http://dx.doi.org/10.1038/s41467-019-08530-5

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