Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis

The ETS transcription factor Fli-1 controls the expression of genes involved in hematopoiesis including cell proliferation, survival, and differentiation. Dysregulation of Fli-1 induces hematopoietic and solid tumors, rendering it an important target for therapeutic intervention. Through high conten...

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Detalles Bibliográficos
Autores principales: Liu, Tangjingjun, Xia, Lei, Yao, Yao, Yan, Chen, Fan, Yanhua, Gajendran, Babu, Yang, Jue, Li, You-Jun, Chen, Juan, Filmus, Jorge, Spaner, David E, Zacksenhaus, Eldad, Hao, Xiaojiang, Ben-David, Yaacov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370842/
https://www.ncbi.nlm.nih.gov/pubmed/30741932
http://dx.doi.org/10.1038/s41419-019-1363-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370842/
https://www.ncbi.nlm.nih.gov/pubmed/30741932
http://dx.doi.org/10.1038/s41419-019-1363-1

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