Cargando…
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis
The ETS transcription factor Fli-1 controls the expression of genes involved in hematopoiesis including cell proliferation, survival, and differentiation. Dysregulation of Fli-1 induces hematopoietic and solid tumors, rendering it an important target for therapeutic intervention. Through high conten...
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370842/ https://www.ncbi.nlm.nih.gov/pubmed/30741932 http://dx.doi.org/10.1038/s41419-019-1363-1 |