Early stages of aggregation of engineered α-synuclein monomers and oligomers in solution

α-Synuclein is a protein that aggregates as amyloid fibrils in the brains of patients with Parkinson’s disease and dementia with Lewy bodies. Small oligomers of α-synuclein are neurotoxic and are thought to be closely associated with disease. Whereas α-synuclein fibrillization and fibril morphologie...

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Detalles Bibliográficos
Autores principales: Li, Xi, Dong, Chunhua, Hoffmann, Marion, Garen, Craig R., Cortez, Leonardo M., Petersen, Nils O., Woodside, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370846/
https://www.ncbi.nlm.nih.gov/pubmed/30741954
http://dx.doi.org/10.1038/s41598-018-37584-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370846/
https://www.ncbi.nlm.nih.gov/pubmed/30741954
http://dx.doi.org/10.1038/s41598-018-37584-6

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