Most canine ameloblastomas harbor HRAS mutations, providing a novel large-animal model of RAS-driven cancer

Canine acanthomatous ameloblastomas (CAA), analogs of human ameloblastoma, are oral tumors of odontogenic origin for which the genetic drivers have remained undefined. By whole-exome sequencing, we have now discovered recurrent HRAS and BRAF activating mutations, respectively, in 63% and 8% of CAA....

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Detalles Bibliográficos
Autores principales: Saffari, Persiana S., Vapniarsky, Natalia, Pollack, Anna S., Gong, Xue, Vennam, Sujay, Pollack, Andrew J., Verstraete, Frank J. M., West, Robert B., Arzi, Boaz, Pollack, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370874/
https://www.ncbi.nlm.nih.gov/pubmed/30741938
http://dx.doi.org/10.1038/s41389-019-0119-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370874/
https://www.ncbi.nlm.nih.gov/pubmed/30741938
http://dx.doi.org/10.1038/s41389-019-0119-1

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