Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules

Enhancing the germinal center (GC) reaction is a prime objective in vaccine development. Targeting of antigen to MHCII on APCs has previously been shown to increase antibody responses, but the underlying mechanism has been unclear. We have here investigated the GC reaction after targeting antigen to...

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Detalles Bibliográficos
Autores principales: Andersen, Tor Kristian, Huszthy, Peter C., Gopalakrishnan, Ramakrishna P., Jacobsen, Johanne T., Fauskanger, Marte, Tveita, Anders A., Grødeland, Gunnveig, Bogen, Bjarne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370881/
https://www.ncbi.nlm.nih.gov/pubmed/30775000
http://dx.doi.org/10.1038/s41541-019-0101-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370881/
https://www.ncbi.nlm.nih.gov/pubmed/30775000
http://dx.doi.org/10.1038/s41541-019-0101-0

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