Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABA(A)Rs) has been implicated in the pathophysiology of FXS. Neuroactive steroids (NASs) are known allosteric modulators of GAB...

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Detalles Bibliográficos
Autores principales: Modgil, Amit, Vien, Thuy N., Ackley, Michael A., Doherty, James J., Moss, Stephen J., Davies, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371020/
https://www.ncbi.nlm.nih.gov/pubmed/30804752
http://dx.doi.org/10.3389/fnmol.2019.00015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371020/
https://www.ncbi.nlm.nih.gov/pubmed/30804752
http://dx.doi.org/10.3389/fnmol.2019.00015

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