Cargando…

Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABA(A)Rs) has been implicated in the pathophysiology of FXS. Neuroactive steroids (NASs) are known allosteric modulators of GAB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Modgil, Amit, Vien, Thuy N., Ackley, Michael A., Doherty, James J., Moss, Stephen J., Davies, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371020/ https://www.ncbi.nlm.nih.gov/pubmed/30804752 http://dx.doi.org/10.3389/fnmol.2019.00015

Ejemplares similares

Preventing Phosphorylation of the GABA(A)R β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids
por: Vien, Thuy N., et al.
Publicado: (2022)

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA(A) receptor positive allosteric modulator
por: Althaus, Alison L., et al.
Publicado: (2020)

Neuroactive Steroids: Receptor Interactions and Responses
por: Tuem, Kald Beshir, et al.
Publicado: (2017)

Analytical Methods for the Determination of Neuroactive Steroids
por: Kaleta, Michal, et al.
Publicado: (2021)

Interneuron Dysfunction and Inhibitory Deficits in Autism and Fragile X Syndrome
por: Nomura, Toshihiro
Publicado: (2021)

Role of Neuroactive Steroids in the Peripheral Nervous System
por: Melcangi, Roberto Cosimo, et al.
Publicado: (2011)

Development of neuroactive steroids for the treatment of postpartum depression
por: Gunduz‐Bruce, Handan, et al.
Publicado: (2021)

Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels
por: Morey, Rajendra A., et al.
Publicado: (2019)

Physiopathological Role of Neuroactive Steroids in the Peripheral Nervous System
por: Falvo, Eva, et al.
Publicado: (2020)

The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback?
por: Jevtovic-Todorovic, Vesna, et al.
Publicado: (2023)

GABAergic neuroactive steroids: a new frontier in bipolar disorders?
por: Carta, Mauro Giovanni, et al.
Publicado: (2012)

GABA Signaling and Neuroactive Steroids in Adrenal Medullary Chromaffin Cells
por: Harada, Keita, et al.
Publicado: (2016)

Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?
por: Belvederi Murri, Martino, et al.
Publicado: (2016)

Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
por: Szczurowska, Ewa, et al.
Publicado: (2022)

Realising the therapeutic potential of neuroactive steroid modulators of the GABA(A) receptor
por: Belelli, Delia, et al.
Publicado: (2019)

The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model
por: Hawkins, Nicole A., et al.
Publicado: (2017)

Kinetic and Structural Determinants for GABA-A Receptor Potentiation by Neuroactive Steroids
por: Akk, Gustav, et al.
Publicado: (2010)

Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals
por: Diviccaro, Silvia, et al.
Publicado: (2021)

Neuroactive Steroid–Gut Microbiota Interaction in T2DM Diabetic Encephalopathy
por: Diviccaro, Silvia, et al.
Publicado: (2023)

Steroid precursors, steroids, neuroactive steroids, and neurosteroids concentrations in serum and saliva of healthy neonatal heifer Holstein calves
por: Aleman, Monica, et al.
Publicado: (2020)

Targeted Therapy of Cognitive Deficits in Fragile X Syndrome
por: Puścian, A., et al.
Publicado: (2022)

Beyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and Emotion
por: Wirth, Michelle M.
Publicado: (2011)

Neuroactive Steroids and Cognitive Functions in First-Episode Psychosis Patients and Their Healthy Siblings
por: Knytl, Pavel, et al.
Publicado: (2019)

Polycystic Ovary Syndrome, Affective Symptoms, and Neuroactive Steroids: a Focus on Allopregnanolone
por: Standeven, Lindsay R., et al.
Publicado: (2021)

Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome
por: Cea-Del Rio, C.A., et al.
Publicado: (2020)

Plasma concentrations of steroid precursors, steroids, neuroactive steroids, and neurosteroids in healthy neonatal foals from birth to 7 days of age
por: Aleman, Monica, et al.
Publicado: (2019)

Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats
por: Sze, Ying, et al.
Publicado: (2020)

Sex‐dependent changes in neuroactive steroid concentrations in the rat brain following acute swim stress
por: Sze, Ying, et al.
Publicado: (2018)

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder
por: Cutler, Andrew J., et al.
Publicado: (2023)

Metabolic alteration of neuroactive steroids and protective effect of progesterone in Alzheimer's disease-like rats
por: Liu, Sha, et al.
Publicado: (2013)

PM335. Neuroactive steroid treatment in the model of focal cerebra ischemia in immature brain
por: Vales, K., et al.
Publicado: (2016)

Circulating Neuroactive Steroid Levels in a Patient With Schizophrenia Who Showed Periodic Catatonia
por: Muneoka, Katsumasa, et al.
Publicado: (2023)

Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids
por: Majeed, Y, et al.
Publicado: (2011)

Neuroactive steroids after estrogen exposure in depressed postmenopausal women treated with sertraline and asymptomatic postmenopausal women
por: Morgan, Melinda L., et al.
Publicado: (2009)

Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression
por: Maguire, Jamie
Publicado: (2019)

From the Gender Gap to Neuroactive Steroids: Exploring Multiple Cases to Further Understand Neuropathic Pain
por: Marinelli, Sara, et al.
Publicado: (2023)

The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome
por: Cea-Del Rio, Christian A., et al.
Publicado: (2014)

Visual motion processing deficits in infants with the fragile X premutation
por: Gallego, Pamela K, et al.
Publicado: (2014)

Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome
por: Lee, Bumwhee, et al.
Publicado: (2020)

Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior
por: Morrow, A. Leslie, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_u2ahu4dn79g2b1uml3t514njm1