Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy

Cardiomyopathy is a leading cause of death for Duchenne muscular dystrophy. Here, we find that the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) can share common ligands but play distinct roles in dystrophic heart and skeletal muscle pathophysiology. Comparisons of their ligand st...

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Detalles Bibliográficos
Autores principales: Heier, Christopher R, Yu, Qing, Fiorillo, Alyson A, Tully, Christopher B, Tucker, Asya, Mazala, Davi A, Uaesoontrachoon, Kitipong, Srinivassane, Sadish, Damsker, Jesse M, Hoffman, Eric P, Nagaraju, Kanneboyina, Spurney, Christopher F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371196/
https://www.ncbi.nlm.nih.gov/pubmed/30745312
http://dx.doi.org/10.26508/lsa.201800186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371196/
https://www.ncbi.nlm.nih.gov/pubmed/30745312
http://dx.doi.org/10.26508/lsa.201800186

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