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Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

The insulin/insulin-like growth factor 1 (IGF1) signaling pathways are implicated in longevity and in progression of Alzheimer’s disease. Previously, we showed that insulin-like growth factor 1 receptor (IGF1R) and downstream signaling transcripts are reduced in astrocytes in human brain with progre...

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Detalles Bibliográficos
Autores principales:	Ratcliffe, Laura E., Vázquez Villaseñor, Irina, Jennings, Luke, Heath, Paul R., Mortiboys, Heather, Schwartzentruber, Aurelie, Karyka, Evangelia, Simpson, Julie E., Ince, Paul G., Garwood, Claire J., Wharton, Stephen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372003/ https://www.ncbi.nlm.nih.gov/pubmed/30056117 http://dx.doi.org/10.1016/j.neuroscience.2018.07.029

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