Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure

[Image: see text] Tetrahydroisoquinoline (THIQ) 6-O-sulfamate-based anticancer agents, inspired by the endogenous steroid 2-methoxyestradiol and its sulfamate derivatives, are further explored for antiproliferative and microtubule disruptor activity. Based on recently designed C3-methyl C7-methoxy-s...

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Detalles Bibliográficos
Autores principales: Dohle, Wolfgang, Prota, Andrea E., Menchon, Grégory, Hamel, Ernest, Steinmetz, Michel O., Potter, Barry V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372245/
https://www.ncbi.nlm.nih.gov/pubmed/30775645
http://dx.doi.org/10.1021/acsomega.8b02879