Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

Genetic variation among orthologous proteins can cause cryptic phenotypic properties that only manifest in changing environments. Such variation may impact the evolvability of proteins, but the underlying molecular basis remains unclear. Here, we performed comparative directed evolution of four orth...

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Detalles Bibliográficos
Autores principales: Baier, Florian, Hong, Nansook, Yang, Gloria, Pabis, Anna, Miton, Charlotte M, Barrozo, Alexandre, Carr, Paul D, Kamerlin, Shina CL, Jackson, Colin J, Tokuriki, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372284/
https://www.ncbi.nlm.nih.gov/pubmed/30719972
http://dx.doi.org/10.7554/eLife.40789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372284/
https://www.ncbi.nlm.nih.gov/pubmed/30719972
http://dx.doi.org/10.7554/eLife.40789

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