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Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins. However, little is known about host factors at the interface between replicase complexes and the host cytoplasm. We engineered a biotin ligase int...

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Detalles Bibliográficos
Autores principales: V'kovski, Philip, Gerber, Markus, Kelly, Jenna, Pfaender, Stephanie, Ebert, Nadine, Braga Lagache, Sophie, Simillion, Cedric, Portmann, Jasmine, Stalder, Hanspeter, Gaschen, Véronique, Bruggmann, Rémy, Stoffel, Michael H, Heller, Manfred, Dijkman, Ronald, Thiel, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372286/
https://www.ncbi.nlm.nih.gov/pubmed/30632963
http://dx.doi.org/10.7554/eLife.42037