FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

Monoubiquitination of histone H2B (H2B-Ub) plays a role in transcription and DNA replication, and is required for normal localization of the histone chaperone, FACT. In yeast, H2B-Ub is deubiquitinated by Ubp8, a subunit of SAGA, and Ubp10. Although they target the same substrate, loss of Ubp8 and U...

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Detalles Bibliográficos
Autores principales: Nune, Melesse, Morgan, Michael T, Connell, Zaily, McCullough, Laura, Jbara, Muhammad, Sun, Hao, Brik, Ashraf, Formosa, Tim, Wolberger, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372288/
https://www.ncbi.nlm.nih.gov/pubmed/30681413
http://dx.doi.org/10.7554/eLife.40988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372288/
https://www.ncbi.nlm.nih.gov/pubmed/30681413
http://dx.doi.org/10.7554/eLife.40988

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