Prevalence of DNA repair gene mutations in localized prostate cancer according to clinical and pathologic features: Association of Gleason score and tumor stage

BACKGROUND: DNA repair gene mutations are present in 8–10% of localized prostate cancers. It is unknown if this is influenced by clinicopathologic factors. METHODS: We interrogated localized prostate adenocarcinomas with tumor DNA sequencing from the TCGA validated (n=333) and Nature Genetics (n=377...

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Detalles Bibliográficos
Autores principales: Marshall, Catherine Handy, Fu, Wei, Wang, Hao, Baras, Alexander S., Lotan, Tamara L., Antonarakis, Emmanuel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372344/
https://www.ncbi.nlm.nih.gov/pubmed/30171229
http://dx.doi.org/10.1038/s41391-018-0086-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372344/
https://www.ncbi.nlm.nih.gov/pubmed/30171229
http://dx.doi.org/10.1038/s41391-018-0086-1

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