NOX2 inhibition reduces oxidative stress and prolongs survival in murine KRAS-induced myeloproliferative disease

Mutations leading to constitutive RAS activation contribute in myeloid leukemogenesis. RAS mutations in myeloid cells are accompanied by excessive formation of reactive oxygen species (ROS), but the source of ROS and their role for the initiation and progression of leukemia have not been clearly def...

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Detalles Bibliográficos
Autores principales: Aydin, Ebru, Hallner, Alexander, Grauers Wiktorin, Hanna, Staffas, Anna, Hellstrand, Kristoffer, Martner, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372471/
https://www.ncbi.nlm.nih.gov/pubmed/30323311
http://dx.doi.org/10.1038/s41388-018-0528-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372471/
https://www.ncbi.nlm.nih.gov/pubmed/30323311
http://dx.doi.org/10.1038/s41388-018-0528-1

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