D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors

Vulnerability for cocaine abuse in humans is associated with low dopamine D2 receptor (D2R) availability in the striatum. The mechanisms driving this vulnerability are poorly understood. In this study, we found that downregulating D2R expression selectively in striatal indirect-pathway neurons trigg...

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Detalles Bibliográficos
Autores principales: Dobbs, Lauren K., Kaplan, Alanna R., Bock, Roland, Phamluong, Khanhky, Shin, J. Hoon, Bocarsly, Miriam E., Eberhart, Lindsay, Ron, Dorit, Alvarez, Veronica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372593/
https://www.ncbi.nlm.nih.gov/pubmed/30504927
http://dx.doi.org/10.1038/s41386-018-0286-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372593/
https://www.ncbi.nlm.nih.gov/pubmed/30504927
http://dx.doi.org/10.1038/s41386-018-0286-3

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