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D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors
Vulnerability for cocaine abuse in humans is associated with low dopamine D2 receptor (D2R) availability in the striatum. The mechanisms driving this vulnerability are poorly understood. In this study, we found that downregulating D2R expression selectively in striatal indirect-pathway neurons trigg...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372593/ https://www.ncbi.nlm.nih.gov/pubmed/30504927 http://dx.doi.org/10.1038/s41386-018-0286-3 |