Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer’s disease, Prion diseases, type...

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Autores principales: Yang, Yang, Wang, Huanan, Kouadir, Mohammed, Song, Houhui, Shi, Fushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372664/
https://www.ncbi.nlm.nih.gov/pubmed/30755589
http://dx.doi.org/10.1038/s41419-019-1413-8
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author Yang, Yang
Wang, Huanan
Kouadir, Mohammed
Song, Houhui
Shi, Fushan
author_facet Yang, Yang
Wang, Huanan
Kouadir, Mohammed
Song, Houhui
Shi, Fushan
author_sort Yang, Yang
collection PubMed
description The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer’s disease, Prion diseases, type 2 diabetes, and some infectious diseases. It has been found that a variety of stimuli including danger-associated molecular patterns (DAMPs, such as silica and uric acid crystals) and pathogen-associated molecular patterns (PAMPs) can activate NLRP3 inflammasome, but the specific regulatory mechanisms of NLRP3 inflammasome activation remain unclear. Understanding the mechanisms of NLRP3 activation will enable the development of its specific inhibitors to treat NLRP3-related diseases. In this review, we summarize current understanding of the regulatory mechanisms of NLRP3 inflammasome activation as well as inhibitors that specifically and directly target NLRP3.
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spelling pubmed-63726642019-02-13 Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors Yang, Yang Wang, Huanan Kouadir, Mohammed Song, Houhui Shi, Fushan Cell Death Dis Review Article The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer’s disease, Prion diseases, type 2 diabetes, and some infectious diseases. It has been found that a variety of stimuli including danger-associated molecular patterns (DAMPs, such as silica and uric acid crystals) and pathogen-associated molecular patterns (PAMPs) can activate NLRP3 inflammasome, but the specific regulatory mechanisms of NLRP3 inflammasome activation remain unclear. Understanding the mechanisms of NLRP3 activation will enable the development of its specific inhibitors to treat NLRP3-related diseases. In this review, we summarize current understanding of the regulatory mechanisms of NLRP3 inflammasome activation as well as inhibitors that specifically and directly target NLRP3. Nature Publishing Group UK 2019-02-12 /pmc/articles/PMC6372664/ /pubmed/30755589 http://dx.doi.org/10.1038/s41419-019-1413-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Yang, Yang
Wang, Huanan
Kouadir, Mohammed
Song, Houhui
Shi, Fushan
Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
title Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
title_full Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
title_fullStr Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
title_full_unstemmed Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
title_short Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
title_sort recent advances in the mechanisms of nlrp3 inflammasome activation and its inhibitors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372664/
https://www.ncbi.nlm.nih.gov/pubmed/30755589
http://dx.doi.org/10.1038/s41419-019-1413-8
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