Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure−activity relationship with a strong BBB permeability

We extracted 15 pterosin derivatives from Pteridium aquilinum that inhibited β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and cholinesterases involved in the pathogenesis of Alzheimer’s disease (AD). (2R)-Pterosin B inhibited BACE1, acetylcholinesterase (AChE) and butyrylcholinesterase...

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Detalles Bibliográficos
Autores principales: Jannat, Susoma, Balupuri, Anand, Ali, Md Yousof, Hong, Seong Su, Choi, Chun Whan, Choi, Yun-Hyeok, Ku, Jin-Mo, Kim, Woo Jung, Leem, Jae Yoon, Kim, Ju Eun, Shrestha, Abinash Chandra, Ham, Ha Neul, Lee, Kee-Ho, Kim, Dong Min, Kang, Nam Sook, Park, Gil Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372667/
https://www.ncbi.nlm.nih.gov/pubmed/30755593
http://dx.doi.org/10.1038/s12276-019-0205-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372667/
https://www.ncbi.nlm.nih.gov/pubmed/30755593
http://dx.doi.org/10.1038/s12276-019-0205-7

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