Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

Hypoxia-inducible factor-1α (HIF-1α) mediates tumor cell adaptation to hypoxic conditions and is a potentially important anticancer therapeutic target. We previously developed a method for synthesizing a benzofuran-based natural product, (R)-(-)-moracin-O, and obtained a novel potent analog, MO-460...

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Detalles Bibliográficos
Autores principales: Soung, Nak-Kyun, Kim, Hye-Min, Asami, Yukihiro, Kim, Dong Hyun, Cho, Yangrae, Naik, Ravi, Jang, Yerin, Jang, Kusic, Han, Ho Jin, Ganipisetti, Srinivas Rao, Cha-Molstad, Hyunjoo, Hwang, Joonsung, Lee, Kyung Ho, Ko, Sung-Kyun, Jang, Jae-Hyuk, Ryoo, In-Ja, Kwon, Yong Tae, Lee, Kyung Sang, Osada, Hiroyuki, Lee, Kyeong, Kim, Bo Yeon, Ahn, Jong Seog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372683/
https://www.ncbi.nlm.nih.gov/pubmed/30755586
http://dx.doi.org/10.1038/s12276-018-0200-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372683/
https://www.ncbi.nlm.nih.gov/pubmed/30755586
http://dx.doi.org/10.1038/s12276-018-0200-4

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