Gene silencing based on RNA-guided catalytically inactive Cas9 (dCas9): a new tool for genetic engineering in Leptospira

Leptospirosis is a worldwide zoonosis caused by pathogenic bacteria of the genus Leptospira, which also includes free-living saprophyte strains. Many aspects of leptospiral basic biology and virulence mechanisms remain unexplored mainly due to the lack of effective genetic tools available for these...

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Detalles Bibliográficos
Autores principales: Fernandes, L. G. V., Guaman, L. P., Vasconcellos, S. A., Heinemann, Marcos B., Picardeau, M., Nascimento, A. L. T. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372684/
https://www.ncbi.nlm.nih.gov/pubmed/30755626
http://dx.doi.org/10.1038/s41598-018-37949-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372684/
https://www.ncbi.nlm.nih.gov/pubmed/30755626
http://dx.doi.org/10.1038/s41598-018-37949-x

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