Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

Secretion of interleukin-1β (IL-1β) represents a fundamental innate immune response to microbial infection that, at the molecular level, occurs following activation of proteolytic caspases that cleave the immature protein into a secretable form. Human cytomegalovirus (HCMV) is the archetypal betaher...

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Detalles Bibliográficos
Autores principales: Botto, Sara, Abraham, Jinu, Mizuno, Nobuyo, Pryke, Kara, Gall, Bryan, Landais, Igor, Streblow, Daniel N., Fruh, Klaus J., DeFilippis, Victor R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372796/
https://www.ncbi.nlm.nih.gov/pubmed/30755509
http://dx.doi.org/10.1128/mBio.02510-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372796/
https://www.ncbi.nlm.nih.gov/pubmed/30755509
http://dx.doi.org/10.1128/mBio.02510-18

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