Cargando…
Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data
BACKGROUND: Genetically engineered mice (GEM) are essential tools for understanding gene function and disease modeling. Historically, gene targeting was first done in embryonic stem cells (ESCs) derived from the 129 family of inbred strains, leading to a mixed background or congenic mice when crosse...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373082/ https://www.ncbi.nlm.nih.gov/pubmed/30755158 http://dx.doi.org/10.1186/s12864-019-5504-9 |