Oral administration of irinotecan in patients with solid tumors: an open-label, phase I, dose escalating study evaluating safety, tolerability and pharmacokinetics

BACKGROUND: Oral drug formulations have several advantages compared to intravenous formulation. Apart from patient convenience and favorable pharmacoeconomics, they offer the possibility of frequent drug administration at home. In this study, we present a new oral irinotecan formulation designed as...

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Detalles Bibliográficos
Autores principales: Kümler, I., Sørensen, P. Grundtvig, Palshof, J., Høgdall, E., Skovrider-Ruminski, W., Theile, S., Fullerton, A., Nielsen, P. G., Jensen, B. Vittrup, Nielsen, D. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373187/
https://www.ncbi.nlm.nih.gov/pubmed/30406838
http://dx.doi.org/10.1007/s00280-018-3720-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373187/
https://www.ncbi.nlm.nih.gov/pubmed/30406838
http://dx.doi.org/10.1007/s00280-018-3720-7

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