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Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma

PURPOSE: Glioblastoma is still intractable despite the progress in therapies, and the intractability is attributable to a minor population of stem-like tumor cells. As a niche harboring quiescent stem-like tumor cells with potentially high tumorigenicity, we have specified an area around large ische...

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Detalles Bibliográficos
Autores principales: Kimura, Tokuhiro, Cui, Dan, Kawano, Hiroo, Yoshitomi-Sakamoto, Chihiro, Takakura, Nobuyuki, Ikeda, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373247/
https://www.ncbi.nlm.nih.gov/pubmed/30465075
http://dx.doi.org/10.1007/s00432-018-2797-z