Distribution of Protein Content and Number of Aggregates in Monoclonal Antibody Formulation After Large-Scale Freezing

Cryoconcentration of an in-house IgG(1) and number of aggregates in a formulation containing trehalose were determined in dependence on freezing protocol and volume. Morphology changes of ice crystals depending on cooling rates were captured by optical cryomicroscopy (OCM) images. UV-Vis and affinit...

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Detalles Bibliográficos
Autores principales: Hauptmann, Astrid, Hoelzl, Georg, Loerting, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373418/
https://www.ncbi.nlm.nih.gov/pubmed/30631964
http://dx.doi.org/10.1208/s12249-018-1281-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373418/
https://www.ncbi.nlm.nih.gov/pubmed/30631964
http://dx.doi.org/10.1208/s12249-018-1281-z

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