Fenofibrate Decreases Hepatic P-Glycoprotein in a Rat Model of Hereditary Hypertriglyceridemia

P-glycoprotein (P-gp) is a membrane-bound transporter encoded by Mdr1a/Abcb1a and Mdr1b/Abcb1b genes in rodents involved in the efflux of cytotoxic chemicals and metabolites from cells. Modulation of its activity influences P-gp-mediated drug delivery and drug-drug interaction (DDI). In the current...

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Detalles Bibliográficos
Autores principales: Poruba, Martin, Matuskova, Zuzana, Hüttl, Martina, Malinska, Hana, Oliyarnyk, Olena, Markova, Irena, Gurska, Sona, Kazdova, Ludmila, Vecera, Rostislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373460/
https://www.ncbi.nlm.nih.gov/pubmed/30787874
http://dx.doi.org/10.3389/fphar.2019.00056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373460/
https://www.ncbi.nlm.nih.gov/pubmed/30787874
http://dx.doi.org/10.3389/fphar.2019.00056

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