The Binding of Human IgG to Minipig FcγRs – Implications for Preclinical Assessment of Therapeutic Antibodies

PURPOSE: The Göttingen minipig is a relevant non-rodent species for regulatory toxicological studies. Yet, its use with therapeutic antibodies has been limited by the unknown binding properties of human immunoglobulins (huIgG) to porcine Fc gamma receptors (poFcγR) influencing safety and efficacy re...

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Detalles Bibliográficos
Autores principales: Egli, Jerome, Schlothauer, Tilman, Spick, Christian, Seeber, Stefan, Singer, Thomas, Odermatt, Alex, Iglesias, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373530/
https://www.ncbi.nlm.nih.gov/pubmed/30721414
http://dx.doi.org/10.1007/s11095-019-2574-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373530/
https://www.ncbi.nlm.nih.gov/pubmed/30721414
http://dx.doi.org/10.1007/s11095-019-2574-y

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