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SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress
Sirtuin 5 (SIRT5) is a member of the NAD(+)-dependent sirtuin family of protein deacylase that catalyzes removal of post-translational modifications, such as succinylation, malonylation, and glutarylation on lysine residues. In light of the SIRT5's roles in regulating mitochondrion function, we...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373945/ https://www.ncbi.nlm.nih.gov/pubmed/30759120 http://dx.doi.org/10.1371/journal.pone.0211796 |