SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress

Sirtuin 5 (SIRT5) is a member of the NAD(+)-dependent sirtuin family of protein deacylase that catalyzes removal of post-translational modifications, such as succinylation, malonylation, and glutarylation on lysine residues. In light of the SIRT5's roles in regulating mitochondrion function, we...

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Detalles Bibliográficos
Autores principales: Zhang, Mengli, Wu, Jian, Sun, Renqiang, Tao, Xiaoting, Wang, Xiaoxia, Kang, Qi, Wang, Hui, Zhang, Lei, Liu, Peng, Zhang, Jinye, Xia, Yukun, Zhao, Yuzheng, Yang, Yi, Xiong, Yue, Guan, Kun-Liang, Zou, Yunzeng, Ye, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373945/
https://www.ncbi.nlm.nih.gov/pubmed/30759120
http://dx.doi.org/10.1371/journal.pone.0211796

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