Using topic modeling via non-negative matrix factorization to identify relationships between genetic variants and disease phenotypes: A case study of Lipoprotein(a) (LPA)

Genome-wide and phenome-wide association studies are commonly used to identify important relationships between genetic variants and phenotypes. Most studies have treated diseases as independent variables and suffered from the burden of multiple adjustment due to the large number of genetic variants...

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Detalles Bibliográficos
Autores principales: Zhao, Juan, Feng, QiPing, Wu, Patrick, Warner, Jeremy L., Denny, Joshua C., Wei, Wei-Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374022/
https://www.ncbi.nlm.nih.gov/pubmed/30759150
http://dx.doi.org/10.1371/journal.pone.0212112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374022/
https://www.ncbi.nlm.nih.gov/pubmed/30759150
http://dx.doi.org/10.1371/journal.pone.0212112

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