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p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise

In the neurogenic niches—the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles—stem cells continue to divide during adulthood, generating progenitor cells and new neurons, and to self-renew, thus maintaining the stem cell pool. During aging, the number...

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Detalles Bibliográficos
Autores principales: Micheli, Laura, D’Andrea, Giorgio, Ceccarelli, Manuela, Ferri, Alessandra, Scardigli, Raffaella, Tirone, Felice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374340/
https://www.ncbi.nlm.nih.gov/pubmed/30792628
http://dx.doi.org/10.3389/fncel.2019.00010