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Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma

Glycine-N-methyl transferase (GNMT) a tumor suppressor for hepatocellular carcinoma (HCC) plays a crucial role in liver homeostasis. Its expression is downregulated in almost all the tumor tissues of HCC while the mechanism of this downregulation is not yet fully understood. Recently, we identified...

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Detalles Bibliográficos
Autores principales: Kant, Rajni, Yen, Chia-Hung, Hung, Jung-Hsien, Lu, Chung-Kuang, Tung, Chien-Yi, Chang, Pei-Ching, Chen, Yueh-Hao, Tyan, Yu-Chang, Chen, Yi-Ming Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374375/
https://www.ncbi.nlm.nih.gov/pubmed/30760754
http://dx.doi.org/10.1038/s41598-018-37292-1