Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models

Bcl9 and Pygo are Wnt enhanceosome components that effect β-catenin-dependent transcription. Whether they mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intestinal tumourigenesis initiated by Apc loss-of-function (Apc(Min)), or by Apc(1322T) encoding a partially-func...

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Detalles Bibliográficos
Autores principales: Mieszczanek, Juliusz, van Tienen, Laurens M., Ibrahim, Ashraf E. K., Winton, Douglas J., Bienz, Mariann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374407/
https://www.ncbi.nlm.nih.gov/pubmed/30760710
http://dx.doi.org/10.1038/s41467-018-08164-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374407/
https://www.ncbi.nlm.nih.gov/pubmed/30760710
http://dx.doi.org/10.1038/s41467-018-08164-z

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