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Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models
Bcl9 and Pygo are Wnt enhanceosome components that effect β-catenin-dependent transcription. Whether they mediate β-catenin-dependent neoplasia is unclear. Here we assess their roles in intestinal tumourigenesis initiated by Apc loss-of-function (Apc(Min)), or by Apc(1322T) encoding a partially-func...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374407/ https://www.ncbi.nlm.nih.gov/pubmed/30760710 http://dx.doi.org/10.1038/s41467-018-08164-z |