Sodium current inhibition following stimulation of exchange protein directly activated by cyclic-3′,5′-adenosine monophosphate (Epac) in murine skeletal muscle

We investigated effects of pharmacological triggering of exchange protein directly activated by cyclic-3′,5′-adenosine monophosphate (Epac) on Nav1.4 currents from intact murine (C67BL6) skeletal muscle fibres for the first time. This employed a loose patch clamp technique which examined ionic curre...

Descripción completa

Detalles Bibliográficos
Autores principales: Matthews, Hugh R., Tan, Sapphire R. X., Shoesmith, Jonathan A., Ahmad, Shiraz, Valli, Haseeb, Jeevaratnam, Kamalan, Huang, Christopher L.-H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374420/
https://www.ncbi.nlm.nih.gov/pubmed/30760734
http://dx.doi.org/10.1038/s41598-018-36386-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374420/
https://www.ncbi.nlm.nih.gov/pubmed/30760734
http://dx.doi.org/10.1038/s41598-018-36386-0

Ejemplares similares