Anti-microRNA screen uncovers miR-17 family within miR-17~92 cluster as the primary driver of kidney cyst growth

Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of renal failure. We have recently shown that inhibiting miR-17~92 is a potential novel therapeutic approach for ADPKD. However, miR-17~92 is a polycistronic cluster that encodes microRNAs (miRNAs) belonging to the miR...

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Detalles Bibliográficos
Autores principales: Yheskel, Matanel, Lakhia, Ronak, Cobo-Stark, Patricia, Flaten, Andrea, Patel, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374450/
https://www.ncbi.nlm.nih.gov/pubmed/30760828
http://dx.doi.org/10.1038/s41598-019-38566-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374450/
https://www.ncbi.nlm.nih.gov/pubmed/30760828
http://dx.doi.org/10.1038/s41598-019-38566-y

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