Improvement of antibody functionality by structure-guided paratope engraftment

Broadly neutralizing antibodies (bNAbs) represent a promising alternative to antiretroviral drugs for HIV-1 prevention and treatment. Selected antibodies to the CD4-binding site bolster envelope trimer binding via quaternary contacts. Here, we rationally engraft a new paratope, i.e., the extended he...

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Detalles Bibliográficos
Autores principales: Liu, Qingbo, Lai, Yen-Ting, Zhang, Peng, Louder, Mark K., Pegu, Amarendra, Rawi, Reda, Asokan, Mangaiarkarasi, Chen, Xuejun, Shen, Chen-Hsiang, Chuang, Gwo-Yu, Yang, Eun Sung, Miao, Huiyi, Wang, Yuge, Fauci, Anthony S., Kwong, Peter D., Mascola, John R., Lusso, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374468/
https://www.ncbi.nlm.nih.gov/pubmed/30760721
http://dx.doi.org/10.1038/s41467-019-08658-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374468/
https://www.ncbi.nlm.nih.gov/pubmed/30760721
http://dx.doi.org/10.1038/s41467-019-08658-4

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