Induction of MET Receptor Tyrosine Kinase Down-regulation through Antibody-mediated Receptor Clustering

The proto-oncoprotein MET is a receptor tyrosine kinase that plays a key role in cancer cell growth and invasion. We have used fluorescence-tagged antibodies to activate MET in live serum-starved glioblastoma cells and monitor the fate of antibody-bound MET receptor in single cell-based assays. We f...

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Detalles Bibliográficos
Autores principales: Li, Wenjing, Dick, Adam, Lu, Fei, Zhang, Hui, Sun, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374517/
https://www.ncbi.nlm.nih.gov/pubmed/30760737
http://dx.doi.org/10.1038/s41598-018-36963-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374517/
https://www.ncbi.nlm.nih.gov/pubmed/30760737
http://dx.doi.org/10.1038/s41598-018-36963-3

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