Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity

[Image: see text] As a key player of the protein quality control network of the cell, the molecular chaperone Hsp70 inhibits the aggregation of the amyloid protein tau. To date, the mechanism of this inhibition and the tau species targeted by Hsp70 remain unknown. This is partly due to the inherent...

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Detalles Bibliográficos
Autores principales: Kundel, Franziska, De, Suman, Flagmeier, Patrick, Horrocks, Mathew H., Kjaergaard, Magnus, Shammas, Sarah L., Jackson, Sophie E., Dobson, Christopher M., Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374916/
https://www.ncbi.nlm.nih.gov/pubmed/29300447
http://dx.doi.org/10.1021/acschembio.7b01039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374916/
https://www.ncbi.nlm.nih.gov/pubmed/29300447
http://dx.doi.org/10.1021/acschembio.7b01039

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