Tunable nonenzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency

Degradability of polycations under physiological conditions is an attractive feature for their use in biomedical applications, such as the delivery of nucleic acids. This study aims to design polycations with tunable nonenzymatic degradability. A series of cationic N-substituted polyaspartamides wer...

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Detalles Bibliográficos
Autores principales: Naito, Mitsuru, Otsu, Yuta, Kamegawa, Rimpei, Hayashi, Kotaro, Uchida, Satoshi, Kim, Hyun Jin, Miyata, Kanjiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Focus on Bio-inspired nanomaterials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374946/
https://www.ncbi.nlm.nih.gov/pubmed/30787961
http://dx.doi.org/10.1080/14686996.2019.1569818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374946/
https://www.ncbi.nlm.nih.gov/pubmed/30787961
http://dx.doi.org/10.1080/14686996.2019.1569818

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