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SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination
BACKGROUND: S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that specifically recognizes phosphorylated cell cycle regulator proteins and mediates their ubiquitination. Programmed cell death protein 4 (PDCD4) is a tumor suppressor gene that plays a role in cell apo...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375223/ https://www.ncbi.nlm.nih.gov/pubmed/30760284 http://dx.doi.org/10.1186/s13046-019-1069-3 |